Renal vitamin D receptor expression and vitamin D renoprotection
نویسندگان
چکیده
منابع مشابه
Parathyroid hormone decreases renal vitamin D receptor expression in vivo.
The vitamin D receptor (VDR) is a nuclear transcription factor responsible for mediating the biological activities of 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)]. Renal and parathyroid gland VDR content is an important factor in calcium homeostasis, vitamin D metabolism, and the treatment of secondary hyperparathyroidism and renal osteodystrophy. In these tissues, VDR expression is highly regu...
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Two mouse models in which the vitamin D-binding protein (DBP) or megalin, a DBP receptor, were knocked out have recently confirmed that DBP is essential for normal vitamin D homeostasis, and have revealed a major pathway for vitamin D activation (1, 2). DBP is also known as the group-specific component of serum (Gc-globulin). It is a highly polymorphic 58 kDa glycoprotein, which has been used a...
متن کاملVitamin D, vitamin D receptor and tissue barriers
Tissue barriers are critical in the pathogenesis of human diseases, such as atopic dermatitis, inflammatory bowel diseases, and various cancers. Preserving or restoring barrier functions of the epithelia cells is a therapeutic strategy to prevent and treat the illness. Mounting evidence indicates that vitamin D and the vitamin D receptor (VDR) play key roles in the pathogenesis of human disease...
متن کاملVitamin D Receptor Expression in Dogs
BACKGROUND There is growing evidence linking low blood vitamin D concentration to numerous diseases in people and in dogs. Vitamin D influences cellular function by signaling through the vitamin D receptor (VDR). Little is known about which non-skeletal tissues express the VDR or how inflammation influences its expression in the dog. OBJECTIVES To define which non-skeletal canine tissues expr...
متن کاملVitamin D receptor expression in colorectal cancer.
AIMS To determine whether the vitamin D receptor is expressed in colorectal cancer, and its relation to stage of disease. METHODS Paraffin embedded sections of colorectal cancer from 30 patients who had undergone surgery were studied. Immunohistochemistry using the specific monoclonal antibody 9A7 gamma directed against the nuclear vitamin D receptor was used to identify receptors for the act...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2012
ISSN: 0085-2538
DOI: 10.1038/ki.2012.30